MP was the Scientific coordinator of Genetic Park of Ogliastra, and declares that this does not alter his adherence to all the PLoS ONE policies on sharing data and materials. Parracciani, RS, BF and GL were employees of Genetic Park of Ogliastra, a non-profit Consortium (see for a description of statutory mission) and declare that this does not alter their adherence to all the PLoS ONE policies on sharing data and materials. The funders had no role in study design, data collection and analysis, decision to publish, or preparation of the manuscript.Ĭompeting interests: IP was affiliated with the commercial company Shardna Life Sciences (see details at ) as a temporary collaborator and declares that this does not alter his adherence to all the PLoS ONE policies on sharing data and materials. Sardegna 2000/2006, Asse 3 - Risorse Umane “Progetti di ricerca e innovazione al di sotto della soglia DE MINIMIS”) and PRIN-MIUR 2009. This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.įunding: Work supported by Sardinia Region (P.O.R.
Received: JAccepted: DecemPublished: February 17, 2012Ĭopyright: © 2012 Piras et al. PLoS ONE 7(2):Įditor: Dan Mishmar, Ben-Gurion University of the Negev, Israel (2012) Haplotype Affinities Resolve a Major Component of Goat ( Capra hircus) MtDNA D-Loop Diversity and Reveal Specific Features of the Sardinian Stock. Our results illustrate the effects of breeding practices on the composition of maternal gene pool and identify mtDNA types that may be considered in projects aimed at retrieving the maternal component of the oldest breeds of Sardinia.Ĭitation: Piras D, Doro MG, Casu G, Melis PM, Vaccargiu S, Piras I, et al. Moreover, the relevant amount of inter-farm mtDNA diversity found does not increase proportionally with distance. We found that breeders maintain diversity of matrilines most likely through equalization of the reproductive potential. We identified haplotype groups overrepresented in Sardinian goats as a result of founder effects. The results showed that this assignment system could be reproduced in other studies, capturing the greatest part of haplotype diversity. By using Bayesian analysis, a distance-based tree and a network analysis, we recognized demographically coherent groups of sequences identified by particular subsets of the variable positions. We found that Sardinia mirrors a large quota of mtDNA diversity of Western Eurasia in the number of variable sites, their mutational pattern and allele frequency. We sequenced the mtDNA D-loop in a large sample of animals (1,591) which represents a non-trivial quota of the entire goat population of Sardinia. The aims of this work were 1) to provide an operational definition of meaningful mtDNA units within haplogroup A, 2) to investigate the mechanisms underlying the maintenance of diversity by considering the modes of selection operated by breeders and 3) to identify the peculiarities of Sardinian mtDNA types.
Its phylogenetic dissection would cast light on an important portion of the spread of goat breeding. Goat mtDNA haplogroup A is a poorly resolved lineage absorbing most of the overall diversity and is found in locations as distant as Eastern Asia and Southern Africa.
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